Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity
Author:
Affiliation:
1. Department of Chemistry
2. The Skaggs Institute for Chemical Biology
3. The Scripps Research Institute
4. La Jolla
5. USA
Abstract
An expanded scope of a powerful oxadiazole cycloaddition cascade was used for the total synthesis of 17 synthetic vinblastines systematically modified at C4. Their evaluation defined a surprisingly significant impact and provided an unrecognized role of the C4 substituent on activity.
Funder
National Cancer Institute
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC04146A
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