Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity-Reference-Cited by-同舟云学术

Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity

Published:2017 Issue:2 Volume:8 Page:1560-1569
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yang Shouliang¹²³⁴⁵,Sankar Kuppusamy¹²³⁴⁵,Skepper Colin K.¹²³⁴⁵,Barker Timothy J.¹²³⁴⁵,Lukesh III John C.¹²³⁴⁵,Brody Daniel M.¹²³⁴⁵,Brütsch Manuela M.¹²³⁴⁵,Boger Dale L.¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. The Skaggs Institute for Chemical Biology

3. The Scripps Research Institute

4. La Jolla

5. USA

Abstract

An expanded scope of a powerful oxadiazole cycloaddition cascade was used for the total synthesis of 17 synthetic vinblastines systematically modified at C4. Their evaluation defined a surprisingly significant impact and provided an unrecognized role of the C4 substituent on activity.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC04146A

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