Green acetyl modification of puerarin to form puerarin 6′′-<i>O</i>-acetate using engineered <i>Escherichia coli</i> with favorable pathways and elevated acetyl-CoA supply-Reference-Cited by-同舟云学术

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Green acetyl modification of puerarin to form puerarin 6′′-O-acetate using engineered Escherichia coli with favorable pathways and elevated acetyl-CoA supply

Published:2024 Issue:6 Volume:26 Page:3249-3260
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Wang Xue-Ning¹,Sheng Li¹,Guo Xin-Yi¹,Sun Hua¹,Kong Jian-Qiang¹^ORCID

Affiliation:

1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Biosynthesis of Natural Products & CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs), Beijing, 100050, China

Abstract

Green acetylation of puerarin to form puerarin 6′′-O-acetate using engineered Escherichia coli capable of synthesizing acetyl-CoA.

Funder

National Basic Research Program of China

Natural Science Foundation of Beijing Municipality

Chinese Academy of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/GC/D3GC04474B

Reference37 articles.

1. Puerarin: A Review of Pharmacological Effects

2. The Root Extract of Pueraria lobata and Its Main Compound, Puerarin, Prevent Obesity by Increasing the Energy Metabolism in Skeletal Muscle

3. Direct acylation of flavonoid glycosides with phenolic acids catalysed by Candida antarctica lipase B (Novozym 435®)

4. Anti-oxidative and TNF-α suppressive activities of puerarin derivative (4AC) in RAW264.7 cells and collagen-induced arthritic rats

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