Unraveling the mechanism of enantio-controlling switches of an alcohol dehydrogenase toward sterically small ketone-Reference-Cited by-同舟云学术

Unraveling the mechanism of enantio-controlling switches of an alcohol dehydrogenase toward sterically small ketone

Published:2022 Issue:6 Volume:12 Page:1777-1787
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Jiang Yingying¹²^ORCID,Qu Ge¹²³^ORCID,Sheng Xiang¹²³^ORCID,Tong Feifei²,Sun Zhoutong¹²³^ORCID

Affiliation:

1. University of Chinese Academy of Sciences, Beijing 100049, China

2. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

3. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China

Abstract

Unraveling the mechanism of “Switches” (positions 294 and 295) that specifically control the inversion of product chirality by dry and wet experimental analysis.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CY/D2CY00031H

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4. CuH-Catalyzed Asymmetric Reduction of α,β-Unsaturated Carboxylic Acids to β-Chiral Aldehydes

5. Biocatalytic Asymmetric Reduction of γ‐Keto Esters to Access Optically Active γ‐Aryl‐γ‐butyrolactones

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