Towards potent but less toxic nanopharmaceuticals – lipoic acid bioconjugates of ultrasmall gold nanoparticles with an anticancer drug and addressing unit

Author:

Dzwonek Maciej1234,Załubiniak Dominika1234,Piątek Piotr1234ORCID,Cichowicz Grzegorz56127,Męczynska-Wielgosz Sylwia89104,Stępkowski Tomasz89104,Kruszewski Marcin8910411,Więckowska Agnieszka1234,Bilewicz Renata1234ORCID

Affiliation:

1. Faculty of Chemistry

2. University of Warsaw

3. Warsaw

4. Poland

5. Czochralski Laboratory of Advanced Crystal Engineering

6. Biological and Chemical Research Centre

7. 02-089 Warsaw

8. Center for Radiobiology and Biological Dosimetry

9. Institute of Nuclear Chemistry and Technology

10. 03-195 Warszawa

11. Department of Molecular Biology and Translational Research

Abstract

Modification of ultrasmall gold nanoparticles (AuNPs) with the lipoic acid derivative of folic acid was found to enhance their accumulation in the cancer cell, as compared to AuNPs without addressing units.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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