A dual functional ruthenium arene complex induces differentiation and apoptosis of acute promyelocytic leukemia cells-Reference-Cited by-同舟云学术

A dual functional ruthenium arene complex induces differentiation and apoptosis of acute promyelocytic leukemia cells

Published:2019 Issue:42 Volume:10 Page:9721-9728
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Huang Hai¹²³⁴⁵^ORCID,Cao Kaiming¹²³⁴⁵,Kong Yaqiong⁶⁷⁸⁹⁵,Yuan Siming¹²³⁴⁵,Liu Hongke⁶⁷⁸⁹⁵^ORCID,Wang Yucai¹⁰³⁴⁵^ORCID,Liu Yangzhong¹²³⁴⁵^ORCID

Affiliation:

1. CAS Key Laboratory of Soft Matter Chemistry

2. Department of Chemistry

3. University of Science and Technology of China

4. Hefei

5. China

6. Jiangsu Key Laboratory of Biofunctional Materials

7. College of Chemistry and Materials Science

8. Nanjing Normal University

9. Nanjing

10. School of Life Sciences and Medical Center

Abstract

A dual functional ruthenium arene complex induces differentiation and apoptosis of acute promyelocytic leukemia cells through degradation of PML–RARα and DNA damage.

Funder

National Natural Science Foundation of China

Collaborative Innovation Center of Suzhou Nano Science and Technology

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC03110C

Reference33 articles.

1. Acute promyelocytic leukemia: where did we start, where are we now, and the future

2. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

3. Retinoic acid receptors: From molecular mechanisms to cancer therapy

4. Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

5. Acute promyelocytic leukemia: from highly fatal to highly curable

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