Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1-Reference-Cited by-同舟云学术

Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1

Published:2019 Issue:36 Volume:9 Page:20901-20916
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Dehury Budheswar¹²³⁴,Tang Ning¹²³⁴,Blundell Tom L.⁵⁶⁷⁸,Kepp Kasper P.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Technical University of Denmark

3. DK-2800 Kongens Lyngby

4. Denmark

5. Department of Biochemistry

6. University of Cambridge

7. Cambridge

8. UK

Abstract

We constructed a model of presenilin-2 γ-secretase in the membrane and studied it by all-atom molecular dynamics simulations. The study provides the first structural-dynamic comparison of presenilin 1 and 2 relevant to Alzheimer's disease.

Funder

Novo Nordisk Fonden

Sundhed og Sygdom, Det Frie Forskningsråd

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA02623A

Reference110 articles.

1. Alzheimer's Disease International, 2018, 1–48

2. THE FAMILIAL OCCURRENCE OF CREUTZFELDT-JAKOB DISEASE AND ALZHEIMER'S DISEASE

3. Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease

4. The amyloid hypothesis of Alzheimer's disease at 25 years

5. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration

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