NanoSIMS analysis of an isotopically labelled organometallic ruthenium(ii) drug to probe its distribution and state in vitro-Reference-Cited by-同舟云学术

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(ii) drug to probe its distribution and state in vitro

Published:2015 Issue:92 Volume:51 Page:16486-16489
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lee Ronald F. S.¹²³⁴,Escrig Stéphane⁵²³⁴,Croisier Marie⁶²³⁴,Clerc-Rosset Stéphanie⁶²³⁴,Knott Graham W.⁶²³⁴,Meibom Anders⁵²³⁴⁷,Davey Curt A.⁸⁹¹⁰¹¹¹²,Johnsson Kai¹²³⁴,Dyson Paul J.¹²³⁴

Affiliation:

1. Institute of Chemical Sciences and Engineering

2. Ecole Polytechnique Fédérale de Lausanne (EPFL)

3. CH-1015 Lausanne

4. Switzerland

5. Laboratory for Biological Geochemistry

6. Interdisciplinary Centre for Electron Microscopy

7. Center for Advanced Surface Analysis

8. Division of Structural Biology and Biochemistry

9. School of Biological Sciences

10. Nanyang Technological University

11. Singapore 637551

12. Singapore

Abstract

The in vitro inter- and intra-cellular distribution of an isotopically labelled ruthenium(ii)–arene (RAPTA) anti-metastatic compound in human ovarian cancer cells was imaged using nano-scale secondary ion mass spectrometry (NanoSIMS).

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC06983A

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