Dynamic interactions and intracellular fate of label-free, thin graphene oxide sheets within mammalian cells: role of lateral sheet size-Reference-Cited by-同舟云学术

Dynamic interactions and intracellular fate of label-free, thin graphene oxide sheets within mammalian cells: role of lateral sheet size

Published:2021 Issue:14 Volume:3 Page:4166-4185
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Chen Yingxian¹²³⁴⁵,Rivers-Auty Jack⁶⁷²⁸⁹,Crică Livia Elena¹²³⁴⁵,Barr Katie¹²³⁴⁵,Rosano Vinicio¹²³⁴⁵,Arranz Adrián Esteban¹²³⁴⁵,Loret Thomas¹²³⁴⁵,Spiller David¹⁰¹¹²³⁴,Bussy Cyrill¹²³⁴⁵^ORCID,Kostarelos Kostas¹²³⁴⁵^ORCID,Vranic Sandra¹²³⁴⁵^ORCID

Affiliation:

1. Nanomedicine Lab

2. Faculty of Biology, Medicine and Health

3. The University of Manchester

4. Manchester M13 9PT

5. UK

6. Division of Neuroscience and Experimental Psychology

7. School of Biological Sciences

8. Manchester Academic Health Science Centre

9. University of Manchester

10. FBMH Platform Sciences, Enabling Technologies & Infrastructure

11. FBMH Research & Innovation

Abstract

This study reveals the dependence of GO uptake mechanism on its lateral dimensions. The main uptake mechanism of s-GO shifts from macropinocytosis (4 h) to clathrin-dependent endocytosis (24 h), mediated by upregulation of mTORC1/2 pathway.

Funder

Engineering and Physical Sciences Research Council

Graphene Flagship

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NA/D1NA00133G

Reference81 articles.

1. Graphene-based papers as substrates for cell growth: Characterisation and impact on mammalian cells

2. Graphene materials as 2D non-viral gene transfer vector platforms