A combinatorial approach towards the synthesis of non-hydrolysable triazole–iduronic acid hybrid inhibitors of human α-l-iduronidase: discovery of enzyme stabilizers for the potential treatment of MPSI-Reference-Cited by-同舟云学术

A combinatorial approach towards the synthesis of non-hydrolysable triazole–iduronic acid hybrid inhibitors of human α-l-iduronidase: discovery of enzyme stabilizers for the potential treatment of MPSI

Published:2018 Issue:21 Volume:54 Page:2647-2650
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Cheng Wei-Chieh¹²³⁴⁵^ORCID,Lin Cheng-Kun¹²³⁴,Li Huang-Yi⁶⁷³⁴,Chang Yu-Chien⁵⁸⁹⁴,Lu Sheng-Jhih¹²³⁴,Chen Yu-Shin¹²³⁴,Chang Shih-Ying¹²³⁴

Affiliation:

1. Genomics Research Center

2. Academia Sinica

3. Taipei

4. Taiwan

5. Department of Chemistry

6. Department of Life Sciences and Institute of Genome Sciences

7. National Yang-Ming University

8. National Cheng Kung University

9. Tainan City

Abstract

Synthesis and bioevaluation of substituent-diverse triazole–iduronic acid hybrid molecules are highlighted.

Funder

Academia Sinica

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C7CC09642A

Reference37 articles.

1. Insights into mucopolysaccharidosis I from the structure and action of α-L-iduronidase

2. Therapy for the mucopolysaccharidoses

3. Hematopoietic stem cell transplantation improves the high incidence of neutralizing allo-antibodies observed in Hurler's syndrome after pharmacological enzyme replacement therapy

4. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase

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