A combinatorial approach towards the synthesis of non-hydrolysable triazole–iduronic acid hybrid inhibitors of human α-l-iduronidase: discovery of enzyme stabilizers for the potential treatment of MPSI

Author:

Cheng Wei-Chieh12345ORCID,Lin Cheng-Kun1234,Li Huang-Yi6734,Chang Yu-Chien5894,Lu Sheng-Jhih1234,Chen Yu-Shin1234,Chang Shih-Ying1234

Affiliation:

1. Genomics Research Center

2. Academia Sinica

3. Taipei

4. Taiwan

5. Department of Chemistry

6. Department of Life Sciences and Institute of Genome Sciences

7. National Yang-Ming University

8. National Cheng Kung University

9. Tainan City

Abstract

Synthesis and bioevaluation of substituent-diverse triazole–iduronic acid hybrid molecules are highlighted.

Funder

Academia Sinica

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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