Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies-Reference-Cited by-同舟云学术

Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies

Published:2021 Issue:28 Volume:12 Page:9759-9769
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Huang Bo-Cheng¹²³⁴,Lu Yun-Chi⁵⁶³⁴⁷,Liao Jun-Min⁵⁶³⁴⁷,Liu Hui-Ju⁸⁹⁶³⁴,Hong Shih-Ting⁸⁹⁶³⁴,Hsieh Yuan-Chin¹⁰¹¹³⁴,Chuang Chih-Hung⁷⁶³⁴¹²,Chen Huei-Jen⁸⁹⁶³⁴,Liao Tzu-Yi⁸⁹⁶³⁴,Ho Kai-Wen⁸⁹⁶³⁴,Wang Yeng-Tseng¹³⁶³⁴^ORCID,Cheng Tian-Lu¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Biomedical Sciences

2. National Sun Yat-Sen University

3. Kaohsiung

4. Taiwan

5. Department of Biomedical Science and Environmental Biology

6. Kaohsiung Medical University

7. Drug Development and Value Creation Research Center

8. Graduate Institute of Medicine

9. College of Medicine

10. School of Medicine for International Students

11. I-Shou University

12. Department of Medical Laboratory Science and Biotechnology

13. Department of Biochemistry

Abstract

The pro-Ab blocks the Ag binding site using an Ab lock. We designed a method which uses structure-based computational simulation (MSCS) to predict the cover rate of Ab locks with various linkers and select the suitable linker for each Ab.

Funder

Ministry of Science and Technology, Taiwan

Academia Sinica

National Health Research Institutes

Kaohsiung Medical University

Ministry of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01748A