Atom and step economical synthesis of acyclic quaternary centers <i>via</i> iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes-Reference-Cited by-同舟云学术

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Atom and step economical synthesis of acyclic quaternary centers via iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes

Published:2022 Issue:37 Volume:13 Page:11183-11189
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Cooper Phillippa¹,Dalling Andrew G.¹,Farrar Elliot H. E.²^ORCID,Aldhous Timothy P.¹³^ORCID,Grélaud Simon¹,Lester Eleanor¹,Feron Lyman J.⁴,Kemmitt Paul D.⁴,Grayson Matthew N.²^ORCID,Bower John F.³^ORCID

Affiliation:

1. School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK

2. Department of Chemistry, University of Bath, Bath, BA2 7AY, UK

3. Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK

4. Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK

Abstract

Quaternary benzylic centers are accessed with high atom and step economy by intermolecular Ir-catalyzed hydroarylation of non-polarized 1,1-disubstituted alkenes.

Funder

Engineering and Physical Sciences Research Council

European Research Council

AstraZeneca

Leverhulme Trust

University of Bath

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02790A

Reference42 articles.

1. Acyclic Quaternary Carbon Stereocenters via Enantioselective Transition Metal Catalysis

2. All-carbon quaternary centers in natural products and medicinal chemistry: recent advances

3. Catalytic enantioselective synthesis of quaternary carbon stereocentres

4. Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

5. Pharmaceuticals that contain polycyclic hydrocarbon scaffolds

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