Measuring proteins in H2O with 2D-IR spectroscopy-Reference-Cited by-同舟云学术

Measuring proteins in H2O with 2D-IR spectroscopy

Published:2019 Issue:26 Volume:10 Page:6448-6456
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hume Samantha¹²³⁴⁵,Hithell Gordon¹²³⁴⁵,Greetham Gregory M.⁶⁷⁸⁹⁵,Donaldson Paul M.⁶⁷⁸⁹⁵,Towrie Michael⁶⁷⁸⁹⁵,Parker Anthony W.⁶⁷⁸⁹⁵^ORCID,Baker Matthew J.¹⁰¹¹²¹²⁴^ORCID,Hunt Neil T.¹³¹⁴¹⁵¹⁶⁵^ORCID

Affiliation:

1. Department of Physics

2. University of Strathclyde

3. SUPA

4. Glasgow

5. UK

6. STFC Central Laser Facility

7. Research Complex at Harwell

8. Rutherford Appleton Laboratory

9. Didcot

10. WestCHEM

11. Department of Pure and Applied Chemistry

12. Technology and Innovation Centre

13. Department of Chemistry

14. York Biomedical Research Institute

15. University of York

16. York

Abstract

2D-IR spectroscopy is used to measure protein amide I bands in water, avoiding the need for deuteration. We show that H/D exchange affects protein vibrational relaxation dynamics and that the ability to perform 2D-IR in water enables blood serum protein analysis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC01590F

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