Synthesis of spirobarbiturate-pyrrolidinones via a domino aza-Michael/SN2 cyclization of barbiturate-derived alkenes with N-alkoxy α-haloamides-Reference-Cited by-同舟云学术

Synthesis of spirobarbiturate-pyrrolidinones via a domino aza-Michael/SN2 cyclization of barbiturate-derived alkenes with N-alkoxy α-haloamides

Published:2019 Issue:41 Volume:17 Page:9200-9208
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Chuan-Chuan¹²³⁴⁵^ORCID,Zhou Jing⁶⁷⁸⁹¹⁰,Ma Zhi-Wei¹²³⁴,Chen Xiao-Pei¹²³⁴,Chen Ya-Jing⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Faculty of Science

2. Henan University of Animal Husbandry and Economy

3. Zhengzhou 450044

4. PR China

5. College of Chemistry

6. School of Pharmaceutical Sciences

7. Key Laboratory of Advanced Drug Preparation Technologies

8. Ministry of Education of China

9. Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety

10. Zhengzhou University

Abstract

A variety of bioactive spirobarbiturate-3-pyrrolidinones were prepared by a highly efficient domino aza-MIRC reaction of barbiturate-derived alkenes with N-alkoxy α-haloamides under mild conditions.

Funder

Henan University

China Postdoctoral Science Foundation

Key Scientific Research Project of Colleges and Universities in Henan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01992H

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