Structural basis of the mechanism of β-methyl epimerization by enzyme MarH-Reference-Cited by-同舟云学术

Structural basis of the mechanism of β-methyl epimerization by enzyme MarH

Published:2019 Issue:44 Volume:17 Page:9605-9614
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Bin¹²³⁴⁵^ORCID,Hou Yan⁶⁷⁸⁹¹⁰,Wang Xiaozheng¹¹¹²¹³¹⁴⁵,Ma Xiaofang¹²³⁴⁵,Fang Shiqi¹²³⁴⁵,Huang Tao¹²³⁴⁵,Chen Yanli¹²³⁴⁵,Bai Zhiqiang¹²³⁴⁵,Lin Shuangjun¹¹¹²¹³¹⁴⁵^ORCID,Zhang Rundong⁶⁷⁸⁹¹⁰^ORCID,Hu Kaifeng¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Phytochemistry and Plant Resources in West China

2. Kunming Institute of Botany

3. Chinese Academy of Sciences

4. Kunming

5. China

6. Department of Ophthalmology

7. State Key Laboratory of Biotherapy

8. West China Hospital

9. Sichuan University and Collaborative Innovation Center for Biotherapy

10. Chengdu

11. State Key Laboratory of Microbial Metabolism

12. School of Life Sciences & Biotechnology

13. Shanghai Jiao Tong University

14. Shanghai

Abstract

Structures of free MarH and MarH in complex with l-Trp, the analogue of substrate, were determined and the mechanism of MarH-catalyzed stereospecific β-methyl epimerization was proposed.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Yunnan Provincial Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01996K

Reference55 articles.

1. Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds