SC79-loaded ZSM-5/chitosan porous scaffolds with enhanced stem cell osteogenic differentiation and bone regeneration

Author:

Zhu Rong1234,Chen Yi-Xuan5674ORCID,Ke Qin-Fei1234,Gao You-Shui5674,Guo Ya-Ping1234ORCID

Affiliation:

1. The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials

2. Shanghai Normal University

3. Shanghai 200234

4. China

5. Department of Orthopedic Surgery

6. Shanghai Jiao Tong University Affiliated Sixth People's Hospital

7. Shanghai 200233

Abstract

SC79-loaded ZSM-5/chitosan porous scaffolds were fabricated for defined local bone regeneration, and the controlled release of SC79 from therapeutic scaffolds enhanced stem cell osteogenic differentiationviathe activated Wnt/β-catenin signaling pathway.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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