An acyclic enediyne with a furyl tethering group for efficient inhibition of tumor cell viability
Author:
Affiliation:
1. Shanghai Key Laboratory of Advanced Polymeric Materials
2. School of Materials Science and Engineering
3. East China University of Science and Technology
4. Shanghai
5. China
6. The State Key Laboratory of Bioreactor Engineering
Abstract
An acyclic enediyne with a furyl tethering group and two pH-sensitive orthoester groups at the alkynyl termini was synthesized. The introduction of a furyl tethering group represents a new design strategy of “intelligent” antitumor antibiotics that can distinguish tumor and normal cells.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2015/TB/C5TB01867F
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