Bulky cations greatly increase the turnover of a native hammerhead ribozyme-Reference-Cited by-同舟云学术

Bulky cations greatly increase the turnover of a native hammerhead ribozyme

Published:2019 Issue:61 Volume:9 Page:35820-35824
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Nakano Shu-ichi¹²³⁴⁵^ORCID,Yamashita Hirofumi¹²³⁴⁵,Tanabe Kazuya¹²³⁴⁵,Sugimoto Naoki¹²³⁴⁵

Affiliation:

1. Department of Nanobiochemistry

2. Faculty of Frontiers of Innovative Research in Science and Technology (FIRST)

3. Konan University

4. Kobe

5. Japan

Abstract

Large tetraalkylammonium ions increase the turnover rate of the ribozyme derived from an intronic ribozyme in the human genome. The rate can be enhanced by more than a hundred-fold at the optimal concentrations of Mg²⁺ and TPeA ions.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA06797C

Reference46 articles.

1. The distribution of RNA motifs in natural sequences

2. Lead toxicity through the leadzyme

3. A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene

4. A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

5. Intronic hammerhead ribozymes are ultraconserved in the human genome

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2. Single Mutation in Hammerhead Ribozyme Favors Cleavage Activity with Manganese over Magnesium;Non-Coding RNA;2020-03-20