Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots forin vivoHER-2 receptor-targeted imaging-Reference-Cited by-同舟云学术

Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots forin vivoHER-2 receptor-targeted imaging

Published:2018 Issue:53 Volume:54 Page:7314-7317
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wu Yayun¹²³⁴⁵,Chen Zhizhen⁶⁷⁸⁹¹⁰,Zhang Pengfei¹²³⁴⁵^ORCID,Zhou Lihua¹²³⁴⁵,Jiang Tao¹²³⁴⁵,Chen Huajie¹¹¹²¹³¹⁴¹⁵^ORCID,Gong Ping¹²³⁴⁵,Dimitrov Dimiter S.¹⁶¹⁷¹⁸¹⁹,Cai Lintao¹²³⁴⁵^ORCID,Zhao Qi⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Guangdong Key Laboratory of Nanomedicine

2. Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations

3. CAS Key Laboratory of Health Informatics

4. Institute of Biomedicine and Biotechnology

5. Shenzhen Institutes of Advanced Technology

6. Faculty of Health Sciences

7. University of Macau

8. Taipa

9. Macau

10. China

11. Key Laboratory of Advanced Functional Polymeric Materials of College of Hunan Province

12. and Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education

13. College of Chemistry

14. Xiangtan University

15. Xiangtan 411105

16. Center for Antibody Therapeutics

17. University of Pittsburgh Medical School

18. PA

19. USA

Abstract

We produced a new anti-HER2 recombinant fully human antibody identified from a phage-displayed human antibody library, which was conjugated with far-red AIEdots through metal-free click chemistry forin vivotumor-targeted imaging.

Funder

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC03037E

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