Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA-Reference-Cited by-同舟云学术

Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA

Published:2021 Issue:3 Volume:12 Page:416-429
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Singu Padma S.¹²³⁴⁵^ORCID,Chilakamarthi Ushasri⁶²⁷⁴,Mahadik Namita S.⁸²⁷⁴,Keerti Bhamidipati⁸²⁷⁴,Valipenta Narasimhulu¹²³⁴⁵,Mokale Santosh N.⁹¹⁰⁴,Nagesh Narayana¹¹¹²³⁴^ORCID,Kumbhare Ravindra M.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Fluoro-Agrochemicals

2. CSIR-Indian Institute of Chemical Technology

3. Hyderabad 500007

4. India

5. Academy of Scientific and Innovative Research (AcSIR)

6. Polymers and Functional Materials Division

7. Hyderabad-500007

8. Applied Biology Division

9. Y. B. Chavan College of Pharmacy

10. Aurangabad-431001

11. Medical Biotechnology Complex

12. CSIR-Centre for Cellular and Molecular Biology

Abstract

The benzimidazole-1,2,3-triazole hybrid 4f selectively interacted with G-quadruplex DNA over duplex DNA, inhibits cell cycle at the G₂/M phase, inducing apoptosis, and may be a G-quadruplex DNA groove binder with anticancer activity.

Funder

Department of Science and Technology, Ministry of Science and Technology, India

Council of Scientific and Industrial Research, India

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00414F

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