New aryloxy-quinone derivatives as potential anti-Chagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis-Reference-Cited by-同舟云学术

New aryloxy-quinone derivatives as potential anti-Chagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis

Published:2015 Issue:80 Volume:5 Page:65153-65166
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Vázquez Karina¹²³⁴⁵,Espinosa-Bustos Christian¹²³⁴⁵,Soto-Delgado Jorge⁶⁷⁸⁹⁵,Tapia Ricardo A.¹²³⁴⁵,Varela Javier¹⁰¹¹¹²¹³¹⁴,Birriel Estefanía¹⁰¹¹¹²¹³¹⁴,Segura Rodrigo¹⁵¹⁶¹⁷¹⁸⁵,Pizarro Jaime¹⁵¹⁶¹⁷¹⁸⁵,Cerecetto Hugo¹⁰¹¹¹²¹³¹⁴,González Mercedes¹⁰¹¹¹²¹³¹⁴,Paulino Margot¹⁹²¹³¹⁴²⁰,Salas Cristian O.¹²³⁴⁵

Affiliation:

1. Departamento de Química Orgánica

2. Facultad de Química

3. Pontificia Universidad Católica de Chile

4. Santiago 6094411

5. Chile

6. Departamento de Ciencias Químicas

7. Facultad de Ciencias Exactas

8. Universidad Andrés Bello

9. Viña del Mar

10. Grupo de Química Medicinal

11. Instituto de Química Biológica

12. Facultad de Ciencias

13. Universidad de la República

14. Montevideo

15. Departamento de Química de los Materiales

16. Facultad de Química y Biología

17. Universidad de Santiago de Chile

18. Santiago 9170022

19. Centro de Bioinformática Estructural-DETEMA

20. Uruguay

Abstract

A set of new aryloxy-quinones were synthesized and evaluated in vitro against the epimastigote form of Trypanosoma cruzi and their unspecific cytotoxicity was tested on murine macrophages J-774 cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA10122K

Reference51 articles.

1. Neglected Diseases and Poverty in “The Other America”: The Greatest Health Disparity in the United States?

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