Polymorphs and hydrates of the anticancer drug erlotinib: X-ray crystallography, phase transition and biopharmaceutical studies-Reference-Cited by-同舟云学术

Polymorphs and hydrates of the anticancer drug erlotinib: X-ray crystallography, phase transition and biopharmaceutical studies

Published:2021 Issue:22 Volume:23 Page:3961-3974
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Thorat Shridhar H.¹²³⁴⁵,George Christy P.¹²³⁴⁵,Shaligram Parth S.¹²³⁴,P. R. Suresha⁶²³⁴^ORCID,Gonnade Rajesh G.¹²³⁴⁵^ORCID

Affiliation:

1. Physical and Materials Chemistry Division

2. CSIR-National Chemical Laboratory

3. Pune

4. India

5. Academy of Scientific and Innovative Research (AcSIR)

6. Polymer Science and Engineering Division

Abstract

The anticancer drug erlotinib revealed two polymorphs and two hydrates. The metastable polymorph and hydrates converted to the stable polymorph, which displayed solution-mediated transformation into the monohydrate at the lowest water activity.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CE/D1CE00032B

Reference33 articles.

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