Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies-Reference-Cited by-同舟云学术

Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies

Published:2018 Issue:8 Volume:16 Page:1305-1311
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Dovgan Igor¹²³⁴^ORCID,Erb Stéphane⁵⁶⁷⁸⁹,Hessmann Steve⁵⁶⁷⁸⁹,Ursuegui Sylvain¹²³⁴,Michel Chloé¹⁰¹¹⁴,Muller Christian¹²¹³³⁷¹⁴,Chaubet Guilhem¹²³⁴,Cianférani Sarah⁵⁶⁷⁸⁹,Wagner Alain¹²³⁴^ORCID

Affiliation:

1. Laboratory of Functional ChemoSystems (UMR 7199)

2. LabEx Medalis

3. University of Strasbourg

4. France

5. Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO)

6. Université de Strasbourg

7. CNRS

8. IPHC UMR 7178

9. 67000 Strasbourg

10. Syndivia SAS

11. 67400 Illkirch

12. CAMBA

13. IPHC

14. UMR7 178

Abstract

4-Azidophenyl glyoxal enables arginine-selective functionalisation of native antibodies. Being orthogonal to classical lysine conjugation, this method allowed straightforward generation of dual-payload antibody.

Funder

Centre International de Recherche aux Frontières de la Chimie

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02844J

Reference42 articles.

1. Recent advances in the construction of antibody–drug conjugates

2. Strategies and challenges for the next generation of antibody–drug conjugates

3. Immuno-PCR: Very Sensitive Antigen Detection by Means of Specific Antibody-DNA Conjugates