Graphene-extracted membrane lipids facilitate the activation of integrin αvβ8-Reference-Cited by-同舟云学术

Graphene-extracted membrane lipids facilitate the activation of integrin αvβ8

Published:2020 Issue:14 Volume:12 Page:7939-7949
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Chen Serena H.¹²³⁴^ORCID,Perez-Aguilar Jose Manuel⁵⁶⁷⁸⁹,Zhou Ruhong¹²³⁴¹⁰^ORCID

Affiliation:

1. Computational Biology Center

2. IBM Thomas J. Watson Research Center

3. Yorktown Heights

4. USA

5. School of Chemical Sciences

6. Meritorious Autonomous University of Puebla (BUAP)

7. University City

8. Puebla 72570

9. Mexico

10. Institute of Quantitative Biology

Abstract

The β₈ TM domain in integrin α_vβ₈ interacts with inserted graphene nanosheets directly or indirectly through extracted lipids, facilitating the pulling of a β₈ subunit away from an α_v subunit and thus leading to the disruption of the TM domain association and triggering an immune.

Funder

W. M. Keck Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/C9NR10469K

Reference70 articles.

1. Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials

2. Understanding biophysicochemical interactions at the nano–bio interface

3. Strategies in the design of nanoparticles for therapeutic applications