Dichotomous mechanistic behavior in Narasaka–Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals-Reference-Cited by-同舟云学术

Dichotomous mechanistic behavior in Narasaka–Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals

Published:2016 Issue:2 Volume:7 Page:1508-1513
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Race Nicholas J.¹²³⁴,Faulkner Adele¹²³⁴,Shaw Megan H.¹²³⁴,Bower John F.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. University of Bristol

3. Bristol

4. UK

Abstract

Pd-catalyzed cyclizations of oxime esters with pendant alkenes undergo ligand controlled mechanistic divergence. Electron deficient phosphines promote aza-Heck cyclization; electron rich systems favour a SET pathway. Mechanistic experiments differentiate the two manifolds.

Funder

Engineering and Physical Sciences Research Council

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC04037J

Reference49 articles.

1. Analysis of the reactions used for the preparation of drug candidate molecules

2. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates