Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment-Reference-Cited by-同舟云学术

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Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment

Published:2016 Issue:3 Volume:7 Page:2294-2301
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Martínez-Sáez Nuria¹²³⁴⁵,Supekar Nitin T.⁶⁷⁸⁹,Wolfert Margreet A.⁶⁷⁸⁹,Bermejo Iris A.¹²³⁴⁵,Hurtado-Guerrero Ramón¹⁰¹¹¹²¹³¹⁴,Asensio Juan L.¹⁵¹⁶¹⁷⁵,Jiménez-Barbero Jesús¹⁸¹⁹²⁰⁵²¹,Busto Jesús H.¹²³⁴⁵,Avenoza Alberto¹²³⁴⁵,Boons Geert-Jan⁶⁷⁸⁹,Peregrina Jesús M.¹²³⁴⁵,Corzana Francisco¹²³⁴⁵

Affiliation:

1. Departamento de Química

2. Universidad de La Rioja

3. Centro de Investigación en Síntesis Química

4. 26006 Logroño

5. Spain

6. Complex Carbohydrate Research Center

7. University of Georgia

8. Athens

9. USA

10. BIFI

11. University of Zaragoza

12. BIFI-IQFR (CSIC) Joint Unit

13. Mariano Esquillor s/n

14. Campus Rio Ebro

15. Instituto de Química Orgánica General

16. IQOG-CSIC

17. 28006 Madrid

18. Structural Biology Unit

19. CIC bioGUNE

20. 48160 Derio

21. IKERBASQUE

Abstract

Presentation and dynamics of the sugar moiety in MUC1-based vaccines could play a crucial role in the elicitation of a strong immune response.

Funder

Ministerio de Economía y Competitividad

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC04039F

Reference50 articles.

1. The development of synthetic antitumour vaccines from mucin glycopeptide antigens

2. Recent Progress in Antitumoral Synthetic Vaccines

3. Immunotherapy for cancer: synthetic carbohydrate-based vaccines

4. A Vision for Vaccines Built from Fully Synthetic Tumor-Associated Antigens: From the Laboratory to the Clinic

5. Synthetically defined glycoprotein vaccines: current status and future directions

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1. Detection of Tumor‐Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes;Angewandte Chemie International Edition;2024-08-07

2. Detection of Tumor‐Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes;Angewandte Chemie;2024-08-07

3. Multifunctional Lipidated Protein Carrier with a Built-In Adjuvant as a Universal Vaccine Platform Potently Elevates Immunogenicity of Weak Antigens;Journal of Medicinal Chemistry;2024-04-08

4. Synthetic self‐adjuvanted multivalent Mucin 1 (MUC1) glycopeptide vaccines with improved in vivo antitumor efficacy;MedComm;2024-02

5. Mucin1 as a potential molecule for cancer immunotherapy and targeted therapy;Journal of Cancer;2024

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