Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events-Reference-Cited by-同舟云学术

Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events

Published:2020 Issue:19 Volume:56 Page:2881-2884
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Feng Yanqiao¹²³⁴,Su Hui¹²³⁴,Li Yunzhi¹²³⁴,Luo Chunxiang¹²³⁴,Xu Huiying¹²³⁴,Wang Youqiao¹²³⁴,Sun Haixia¹²³⁴,Wan Guohui¹²³⁴^ORCID,Zhou Binhua¹²³⁴⁵^ORCID,Bu Xianzhang¹²³⁴^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Sun Yat-sen University

3. GuangZhou 510006

4. China

5. School of Chinese Pharmacy

Abstract

The first proteolysis targeting chimeras for the intracellular elimination of transforming growth factor-β1 (TGF-β1), which contributes to various diseases, is described.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC08391J

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