Long-term in vivo dissolution of thermo- and pH-responsive, 19F magnetic resonance-traceable and injectable polymer implants

Author:

Jirát-Ziółkowska Natalia12ORCID,Vít Martin1,Groborz Ondřej23ORCID,Kolouchová Kristýna3,Červený David14,Sedláček Ondřej5ORCID,Jirák Daniel14ORCID

Affiliation:

1. Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic

2. Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Katerinska 1660/32, Prague 121 08, Czech Republic

3. Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky square 2, 162 06 Prague, Czech Republic

4. Faculty of Health Studies, Technical University of Liberec, Studentska 1402/2, Liberec 461 17, Czech Republic

5. Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, Prague, 128 00, Czech Republic

Abstract

Thermo- and pH-responsive polymers' dissolution in vivo can be broadly fine-tuned. Polymeric implant can be detected in vivo using “hot-spot” 19F MR measurement. Long-term in vivo dissolution of polymeric implant shows no side effects.

Funder

Ministerstvo Zdravotnictví Ceské Republiky

Grantová Agentura České Republiky

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Royal Society of Chemistry (RSC)

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