SARS-CoV-2 proteins monitored by long-range surface plasmon field-enhanced Raman scattering with hybrid bowtie nanoaperture arrays and nanocavities

Author:

Luo Xiaojun1ORCID,Yue Weiling1,Zhang Shutong1,Liu Haopeng1,Chen Zhinan1,Qiao Ling2,Wu Caijun1,Li Panjie3,He Yi1

Affiliation:

1. School of Science, Xihua University, Chengdu 610039, P. R. China

2. Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore

3. School of Chemistry and Chemical Engineering, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

Abstract

A long-range SERS substrate composed of a bowtie nanoaperture array and a nanocavity is reported. The substrate demonstrated an extended probing distance, stronger E-field strength, and an excellent LOD for the SARS-CoV-2 spike and nucleocapsid proteins, respectively.

Funder

Jiangsu Province

China Scholarship Council

Sichuan Province Science and Technology Support Program

PhD Scientific Research Startup Foundation of Xihua University

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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