An optimised approach for continuous-flow solid-phase peptide synthesis utilising a rudimentary flow reactor-Reference-Cited by-同舟云学术

An optimised approach for continuous-flow solid-phase peptide synthesis utilising a rudimentary flow reactor

Published:2018 Issue:6 Volume:3 Page:875-882
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Spare Lawson K.¹²³⁴^ORCID,Laude Victoire⁵⁶⁷⁸,Harman David G.⁹²⁴¹⁰⁹,Aldrich-Wright Janice R.¹²³⁴¹¹^ORCID,Gordon Christopher P.¹²³⁴¹⁰^ORCID

Affiliation:

1. School of Science and Health

2. Western Sydney University

3. Penrith South DC

4. Australia

5. Sigma Clermont

6. Chemical Engineering Graduate School

7. Aubière

8. France

9. School of Medicine

10. Molecular Medicine Research Group

11. Nanoscale Organisation and Dynamics Group

Abstract

From the repurposing of used HPLC components, a chromatography column, a Rheodyne,® and a heater stirrer, a simple, cost-effective system to conveniently conduct continuous flow solid-phase peptide construction was assembled.

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RE/C8RE00190A

Reference30 articles.

1. Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

2. The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

3. Continuous-Flow Solid-Phase Peptide Synthesis: A Revolutionary Reduction of the Amino Acid Excess

4. Accelerated Synthesis of Protected Peptides in a Continuous-Flow Fixed-Bed Reactor

5. Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing

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