Blocking cyclobutane pyrimidine dimer formation by steric hindrance
Author:
Affiliation:
1. Instituto Universitario Mixto de Tecnología Química (UPV-CSIC)
2. Universitat Politècnica de València
3. Valencia
4. Spain
5. Division of Molecular Science
6. Faculty of Science and Technology
7. Gunma University
8. Kiryu Gunma 376-8515
9. Japan
Abstract
Replacement of the C5 thymine methyl group with a bulky tert-butyl substituent completely blocks the formation of CPDs.
Funder
Consejo Superior de Investigaciones Científicas
Ministerio de Economía y Competitividad
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00382F
Reference15 articles.
1. Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation
2. Characterization of thymidine ultraviolet photoproducts. Cyclobutane dimers and 5,6-dihydrothymidines
3. Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions†
4. Photodimerization of thymine and uracil in acetonitrile
5. Photosensitization of thymine nucleobase by benzophenone through energy transfer, hydrogen abstraction and one-electron oxidation
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3. Photosensitised biphotonic chemistry of pyrimidine derivatives;Organic & Biomolecular Chemistry;2020
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5. Triplet Energy Transfer versus Excited State Cyclization as the Controlling Step in Photosensitized Bipyrimidine Dimerization;The Journal of Organic Chemistry;2019-09-10
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