Enhanced β2-microglobulin binding of a “navigator” molecule bearing a single-chain variable fragment antibody for artificial switching of metabolic processing pathways-Reference-Cited by-同舟云学术

Enhanced β2-microglobulin binding of a “navigator” molecule bearing a single-chain variable fragment antibody for artificial switching of metabolic processing pathways

Published:2021 Issue:16 Volume:9 Page:5551-5558
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Kambe Yusuke¹²³⁴^ORCID,Kuwahara Ken¹²³⁴⁵,Sato Mitsuru⁶⁷⁸⁹¹⁰,Nakaoki Takahiko⁵¹¹¹²⁴,Yamaoka Tetsuji¹²³⁴^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. National Cerebral and Cardiovascular Center (NCVC) Research Institute

3. Osaka 564-8565

4. Japan

5. Department of Materials Chemistry

6. Animal Bioregulation Unit

7. Division of Animal Sciences

8. Institute of Agrobiological Sciences

9. National Agriculture and Food Research Organization (NARO)

10. Tsukuba

11. Ryukoku University

12. Otsu 520-2194

Abstract

Replacement of the β2-microglobulin-binding part of the “navigator” with scFv improved the β2-microglobulin-binding activity in the blood, resulting in better switching of the metabolic processing pathway of the etiologic factor in mice.

Funder

Japan Society for the Promotion of Science

National Cerebral and Cardiovascular Center

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00385B

Reference30 articles.

1. A Novel Strategy for Etiologic Factor Removal: Drug-Navigated Clearance System (DNCS)

2. Artificial switching of the metabolic processing pathway of an etiologic factor, β2-microglobulin, by a “navigator” molecule

3. A new form of amyloid protein associated with chronic hemodialysis was identified as β2-microglobulin

4. Serum Levels of β2-Microglobulin as a New Form of Amyloid Protein in Patients Undergoing Long-Term Hemodialysis

5. Beta-2-Microglobulin and HLA-Related Glycoproteins in Human Urine and Serum

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