Substrate controlled, regioselective carbopalladation for the one-pot synthesis of C4-substituted tetrahydroisoquinoline analogues-Reference-Cited by-同舟云学术

Substrate controlled, regioselective carbopalladation for the one-pot synthesis of C4-substituted tetrahydroisoquinoline analogues

Published:2020 Issue:27 Volume:10 Page:15794-15799
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Krishna Reddy Singarajanahalli Mundarinti¹²³⁴⁵,Suresh Pavithira¹²³⁴⁵,Thamotharan Subbiah⁶⁷²³⁸^ORCID,Nanubolu Jagadeesh Babu⁹¹⁰¹¹⁵,Suresh Surisetti¹²¹⁰¹¹⁵^ORCID,Selva Ganesan Subramaniapillai¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. School of Chemical and Biotechnology

3. SASTRA Deemed University

4. Thanjavur-613401

5. India

6. Biomolecular Crystallography Laboratory

7. Department of Bioinformatics

8. Thanjavur 613401

9. Centre for X-ray Crystallography

10. CSIR-Indian Institute of Chemical Technology

11. Hyderabad-500007

12. Organic Synthesis & Process Chemistry

Abstract

6-Exo-trig cyclization reaction through regioselective carbopalladation was demonstrated with N-(2-halobenzyl)-N-allylamines to furnish the corresponding C4-substituted tetrahydroisoquinoline derivatives.

Funder

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA01539C

Reference29 articles.

1. Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics

2. Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

3. Renieramycin J, a Highly Cytotoxic Tetrahydroisoquinoline Alkaloid, from a Marine Sponge Neopetrosia sp.

4. Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease

5. Substituted tetrahydroisoquinolines: synthesis, characterization, antitumor activity and other biological properties

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