Synthesis of chiral α-substituted α-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation

Author:

Liu Gongyi12345,Zhang Xianghe12345,Wang Heng678910,Cong Hengjiang12345ORCID,Zhang Xumu12345ORCID,Dong Xiu-Qin12345ORCID

Affiliation:

1. Key Laboratory of Biomedical Polymers

2. Engineering Research Center of Organosilicon Compounds & Materials

3. Ministry of Education

4. College of Chemistry and Molecular Sciences

5. Suzhou Institute of Wuhan University

6. Shenzhen Grubbs Institute

7. Department of Chemistry

8. Southern University of Science and Technology

9. Shenzhen

10. P. R. China

Abstract

Efficient Ni-catalyzed asymmetric hydrogenation of cyclic N-sulfonyl ketimino esters and ketimines was successfully developed to prepare a series of chiral α-monosubstituted α-amino acid derivatives and amine derivatives with excellent results.

Funder

Natural Science Foundation of Jiangsu Province

Shenzhen Science and Technology Innovation Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference91 articles.

1. Unnatural Amino Acids: Methods and Protocols , ed. L. Pollegioni and S. Servi , Springer , New York , 2012 , pp. 1–249

2. Amino Acids, Peptides and Proteins in Organic Chemistry , ed. A. B. Hughes , Wiley-VCH , Weinheim , 2009 , vol. 1, pp. 495–526

3. α,β-Diamino Acids:  Biological Significance and Synthetic Approaches

4. Application of Nickel(II) Complexes to the Efficient Synthesis of ?- or ?-Amino Acids

5. Following Universal Prophylaxis with Intravenous Ganciclovir and Cytomegalovirus Immune Globulin, Valganciclovir is Safe and Effective for Prevention of CMV Infection Following Lung Transplantation

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