Inhibiting SARS-CoV-2 viral entry by targeting spike:ACE2 interaction with <i>O</i>-modified quercetin derivatives-Reference-Cited by-同舟云学术

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Inhibiting SARS-CoV-2 viral entry by targeting spike:ACE2 interaction with O-modified quercetin derivatives

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Rosal Reuben James Z.¹^ORCID,Paderes Monissa C.¹^ORCID

Affiliation:

1. Institute of Chemistry, College of Science, University of the Philippines Diliman, Quezon City 1101, Philippines

Abstract

O-Alkylated and acylated quercetin derivatives were found to inhibit SARS-CoV-2 S:ACE2 interaction in vitro and exhibited low hepato-, nephro-, and cardiotoxicity.

Funder

Philippine Council for Health Research and Development

Department of Science and Technology, Republic of the Philippines

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00286E

Reference51 articles.

1. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)

2. Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19

3. A pneumonia outbreak associated with a new coronavirus of probable bat origin

4. WHO Coronavirus (COVID-19) Dashboard, https://covid19.who.int , (accessed 2024-03-04)

5. Structure, Function, and Evolution of Coronavirus Spike Proteins

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