Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome

Author:

Shaw Andrew M.12345ORCID,Hyde Christopher67345,Merrick Blair8910115ORCID,James-Pemberton Philip12345,Squires Bethany K.1213345,Olkhov Rouslan V.12345,Batra Rahul8910115,Patel Amita8910115ORCID,Bisnauthsing Karen8910115,Nebbia Gaia8910115,MacMahon Eithne8910115,Douthwaite Sam914155,Malim Michael914155,Neil Stuart914155,Martinez Nunez Rocio914155,Doores Katie914155,Mark Tan Kia Ik914155ORCID,Signell Adrian W.914155,Betancor Gilberto914155,Wilson Harry D.914155,Galão Rui Pedro914155,Pickering Suzanne914155ORCID,Edgeworth Jonathan D.8910115

Affiliation:

1. Department of Bioscience

2. College of Life and Environmental Sciences

3. University of Exeter

4. Exeter

5. UK

6. Exeter Test Group

7. College of Medicine and Health

8. Centre for Clinical Infection and Diagnostics Research

9. Department of Infectious Diseases

10. Guy's and St Thomas’ NHS Foundation Trust

11. London SE1 7EH

12. Attomarker Ltd

13. Innovation Centre

14. School of Immunology & Microbial Sciences

15. King's College London

Abstract

An evaluation of a rapid portable gold-nanotechnology measuring SARS-CoV-2 IgM, IgA and IgG antibody response to spike 1 (S1), spike 2 (S) and nucleocapsid (N) antigens using serum from 74 RNA(+) patients and RNA(+) 47 control patients.

Funder

University of Exeter

National Institute for Health Research

Medical Research Council

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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