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Metalloprotein design using genetic code expansion

Published:2014 Issue:18 Volume:43 Page:6498-6510
ISSN:0306-0012
Container-title:Chem. Soc. Rev.
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Hu Cheng¹²³,Chan Sunney I.⁴⁵⁶,Sawyer Elizabeth B.¹²³,Yu Yang⁷²⁸,Wang Jiangyun¹²³

Affiliation:

1. Institute of Biophysics

2. Chinese Academy of Sciences

3. Beijing, China

4. Division of Chemistry and Chemical Engineering

5. California Institute of Technology

6. Pasadena, USA

7. Tianjin Institute of Industrial Biotechnology

8. Tianjin 300308, China

Abstract

Genetic code expansion has become an essential new tool for designing functional small protein models for complex metalloenzymes.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CS/C4CS00018H

Reference49 articles.

1. Design of functional metalloproteins

2. Adding New Chemistries to the Genetic Code

3. Biosynthesis of a Site-Specific DNA Cleaving Protein

4. Genetic Incorporation of a Metal-Ion Chelating Amino Acid into Proteins as a Biophysical Probe

5. A Genetically Encoded Bidentate, Metal-Binding Amino Acid

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