Cytotoxic homoleptic Ti(iv) compounds of ONO-type ligands: synthesis, structures and anti-cancer activity

Author:

Manne Rajesh1234,Miller Maya5678,Duthie Andrew9101112,Guedes da Silva M. Fátima C.1314151617ORCID,Tshuva Edit Y.5678,Basu Baul Tushar S.1234ORCID

Affiliation:

1. Centre of Advanced Studies in Chemistry

2. North-Eastern Hill Unversity

3. Shillong 793 022

4. India

5. Institute of Chemistry

6. The Hebrew University of Jerusalem

7. Jerusalem 9190401

8. Israel

9. School of Life and Environmental Science

10. Deakin University

11. Geelong

12. Australia

13. Centro de Quimica Estrutural

14. Complexo I

15. Instituto Superior Tecnico

16. Universidade de Lisboa

17. 1049-001 Lisboa

Abstract

Reacting variously substituted dianionic tridentate ONO-type acylhydrazone ligands with titanium(iv) tetra(isopropoxide) gave a new class of eight homoleptic titanium(iv) compounds showing exceptional stability and promising cytotoxicity.

Funder

H2020 European Research Council

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference70 articles.

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3. Antitumour bis(cyclopentadienyl) metal complexes: titanocene and molybdocene dichloride and derivatives

4. Modern cytotoxic titanium(IV) complexes; Insights on the enigmatic involvement of hydrolysis

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