A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities-Reference-Cited by-同舟云学术

A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities

Published:2020 Issue:28 Volume:18 Page:5339-5343
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Koi Hikari¹²³⁴⁵,Takahashi Norihito¹²³⁴⁵,Fuchi Yasufumi⁶⁷⁸⁵^ORCID,Umeno Tomohiro⁶⁷⁸⁵,Muramatsu Yukiko⁹¹⁰¹¹¹²⁵,Seimiya Hiroyuki⁹¹⁰¹¹¹²⁵,Karasawa Satoru⁶⁷⁸⁵^ORCID,Oguri Hiroki¹³¹⁴¹⁵¹⁶⁵^ORCID

Affiliation:

1. Department of Applied Chemistry

2. Graduate School of Engineering

3. Tokyo University of Agriculture and Technology

4. Koganei

5. Japan

6. Faculty of Pharmaceutical Sciences

7. Showa Pharmaceutical University

8. Machida

9. Division of Molecular Biotherapy

10. Cancer Chemotherapy Center

11. Japanese Foundation for Cancer Research

12. Tokyo

13. Department of Chemistry

14. School of Science

15. The University of Tokyo

16. Bunkyo-ku

Abstract

Appendage of an amphiphilic chain by exploiting the nitrogen installed on the 6-aza-artemisinin imparted self-assembling properties. The fully synthetic 6-aza-artemisinin formed aggregates and exhibited increased in vitro anti-cancer activities.

Funder

Japan Society for the Promotion of Science

Nippon Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00919A

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1. Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine

2. Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin