Lysine residues control the conformational dynamics of beta 2-glycoprotein I-Reference-Cited by-同舟云学术

Lysine residues control the conformational dynamics of beta 2-glycoprotein I

Published:2018 Issue:42 Volume:20 Page:26819-26829
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Buchholz Ina¹²³⁴⁵,Nestler Peter¹²³⁴⁵,Köppen Susan⁶⁷⁴⁸⁷,Delcea Mihaela¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Biochemistry

2. Ernst-Moritz-Arndt University Greifswald

3. 17489 Greifswald

4. Germany

5. ZIK HIKE – Zentrum für Innovationskompetenz

6. Hybrid Materials Interfaces Group, Faculty of Production Engineering, University of Bremen

7. 28359 Bremen

8. Bremen Center for Computational Materials Science

Abstract

We report on a strategy to permanently open up the closed conformation of soluble blood protein beta 2-glycoprotein I by chemical acetylation of lysine residues.

Funder

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP03234C

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5. 2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: Loss of inhibition by clipped 2-glycoprotein I

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