Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation-Reference-Cited by-同舟云学术

Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation

Published:2023 Issue:48 Volume:13 Page:34045-34056
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Cazzoli Riccardo¹,Zamborlin Agata²³,Ermini Maria Laura³,Salerno Antonietta¹,Curcio Manuela⁴,Nicoletta Fiore Pasquale⁴,Iemma Francesca⁴,Vittorio Orazio¹⁵,Voliani Valerio³⁶^ORCID,Cirillo Giuseppe⁴^ORCID

Affiliation:

1. Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia

2. NEST-Scuola Normale Superiore, Piazza San Silvestro, 12 – 56127 Pisa, Italy

3. Center for Nanotechnology Innovation, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12 – 56127 Pisa, Italy

4. Department of Pharmacy Health and Nutritional Science, University of Calabria, 87036 Rende, Italy

5. School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia

6. Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano, 4 – 16148 Genoa, Italy

Abstract

Copper overload or depletion is a valuable strategy in oncology: copper nanoparticles carry out copper-dependent apoptosis via oxidative stress; copper chelators induce apoptosis, inhibit angiogenesis and tumor progression.

Funder

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA06434D

Reference136 articles.

1. In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis

2. Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer Therapeutics

3. The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

4. New force field parameters for metalloproteins I: Divalent copper ion centers including three histidine residues and an oxygen-ligated amino acid residue