Synthesis of plasmodione metabolites and13C-enriched plasmodione as chemical tools for drug metabolism investigation-Reference-Cited by-同舟云学术

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Synthesis of plasmodione metabolites and13C-enriched plasmodione as chemical tools for drug metabolism investigation

Published:2018 Issue:15 Volume:16 Page:2647-2665
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Feng Liwen¹²³⁴⁵^ORCID,Lanfranchi Don Antoine¹²³⁴⁵,Cotos Leandro¹²³⁴⁵,Cesar-Rodo Elena¹²³⁴⁵,Ehrhardt Katharina⁶⁷⁸⁹⁵^ORCID,Goetz Alice-Anne⁶⁷⁸⁹⁵,Zimmermann Herbert¹⁰¹¹¹²¹³^ORCID,Fenaille François¹⁴¹⁵¹⁶⁵^ORCID,Blandin Stephanie A.⁶⁷⁸⁹⁵,Davioud-Charvet Elisabeth¹²³⁴⁵^ORCID

Affiliation:

1. CNRS-Université de Strasbourg-Université de Haute-Alsace UMR 7042

2. Laboratoire d'Innovation Moléculaire et Applications (LIMA)

3. Team Bioorganic and Medicinal Chemistry

4. 67087 Strasbourg

5. France

6. Université de Strasbourg

7. CNRS, Inserm, UPR9022/U1257

8. Mosquito Immune Responses (MIR)

9. F-67000 Strasbourg

10. Max Planck Institut für medizinische Forschung

11. Department of Biomolecular Mechanisms

12. D-69120 Heidelberg

13. Germany

14. CEA Paris-Saclay

15. Laboratoire d'Etudes du Métabolisme des Médicaments (LEMM)

16. 91191 Gif-Sur-Yvette cedex

Abstract

A 10-step synthesis of the antimalarial lead,¹³C₁₈-enriched plasmodione, and of seven putative metabolites is described.

Funder

Agence Nationale de la Recherche

Institut National de la Santé et de la Recherche Médicale

Université de Strasbourg

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00227D

Reference48 articles.

1. World Malaria Report 2017 , World Health Organization , November 29, 2017

2. Plasmodium malariae and Plasmodium ovale – the ‘bashful’ malaria parasites

3. Plasmodium knowlesi: A Malaria Parasite of Monkeys and Humans

4. Plasmodium Species Infecting Children Presenting with Malaria in Uganda

5. CLINICAL ASPECTS OF UNCOMPLICATED AND SEVERE MALARIA

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