A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase-Reference-Cited by-同舟云学术

A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase

Published:2015 Issue:10 Volume:11 Page:2717-2726
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Rudolf Jeffrey D.¹²³⁴,Dong Liao-Bin¹²³⁴,Huang Tingting¹²³⁴,Shen Ben¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. The Scripps Research Institute

3. Jupiter

4. USA

5. Department of Molecular Therapeutics

Abstract

Platensimycin and platencin congeners from overproducing strains support PtmO4 as a long-chain acyl-CoA dehydrogenase catalyzing β-oxidation of the diterpenoid intermediates.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00303B

Reference33 articles.

1. Platensimycin is a selective FabF inhibitor with potent antibiotic properties

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3. Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

4. Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy

5. Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity

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