Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)-Reference-Cited by-同舟云学术

Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)

Published:2021 Issue:5 Volume:2 Page:1474-1478
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Hetherington Kristina¹²,Dutt Som¹²,Ibarra Amaurys A.³,Cawood Emma E.¹²^ORCID,Hobor Fruzsina¹⁴,Woolfson Derek N.³⁵⁶^ORCID,Edwards Thomas A.¹⁴^ORCID,Nelson Adam¹²^ORCID,Sessions Richard B.³⁶^ORCID,Wilson Andrew J.¹²^ORCID

Affiliation:

1. Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

2. School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

3. School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK

4. School of Molecular and Cellular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

5. School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK

6. BrisSynBio, University of Bristol, Life Sciences Building, Tyndall Avenue, Bristol BS8 1TQ, UK

Abstract

An experimentally validated approach for in silico modification of peptide based protein–protein interaction inhibitors is described.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D1CB00137J

Reference43 articles.

1. Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks

2. Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

3. Modulators of Protein–Protein Interactions

4. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

5. A Million Peptide Motifs for the Molecular Biologist

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