Pirfenidone-loaded exosomes derived from pancreatic ductal adenocarcinoma cells alleviate fibrosis of premetastatic niches to inhibit liver metastasis-Reference-Cited by-同舟云学术

Pirfenidone-loaded exosomes derived from pancreatic ductal adenocarcinoma cells alleviate fibrosis of premetastatic niches to inhibit liver metastasis

Published:2022 Issue:22 Volume:10 Page:6614-6626
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhao Jing¹²,Zhu Yun³⁴,Li Zhuojin⁵,Liang Jiawei¹,Zhang Yin¹,Zhou Siqi⁶,Zhang Yixuan¹,Fan Zhiwen⁷,Shen Yonghua¹²,Liu Yifeng⁸,Zhang Feng¹²,Shen Shanshan¹²,Xu Guifang¹,Wang Lei¹²,Lv Ying¹²,Zhang Shu¹²^ORCID,Zou Xiaoping¹²

Affiliation:

1. Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

2. Nanjing University Institute of Pancreatology, Nanjing 210008, China

3. Department of Pharmacy, Nanjing Drum Tower Hospital, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing 210008, China

4. Nanjing Medical Center for Clinical Pharmacy, Nanjing 210008, China

5. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210000, China

6. Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008, China

7. Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

8. College of Pharmacy, Xuzhou Medical University, Xuzhou 221000, China

Abstract

Pirfenidone delivery systems based on pancreatic cancer cell exosomes precisely reach HSCs and alleviate fibrotic microenvironments, thus inhibiting tumour metastasis.

Funder

Medical Science and Technology Development Foundation, Nanjing Municipality Health Bureau

Key Project of Science and Technology Development of Nanjing Medicine

Nanjing Science and Technology Commission

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00770C