Kinetics and mechanism of oxidation of the anti-tubercular prodrug isoniazid and its analog by iridium(iv) as models for biological redox systems-Reference-Cited by-同舟云学术

Kinetics and mechanism of oxidation of the anti-tubercular prodrug isoniazid and its analog by iridium(iv) as models for biological redox systems

Published:2017 Issue:26 Volume:46 Page:8377-8386
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Dong Jingran¹²³⁴⁵,Ren Yanli¹²³⁴⁵,Sun Sufang¹²³⁴⁵,Yang Jiao¹²³⁴⁵,Nan Chunxia¹²³⁴⁵,Shi Hongmei⁶⁷⁸⁵,Xu Jianzhong¹²³⁴⁵,Duan Jie⁶⁷⁸⁵,Shi Tiesheng¹²³⁴⁵^ORCID,Elding Lars I.⁹¹⁰¹¹¹²¹³^ORCID

Affiliation:

1. College of Chemistry and Environmental Science

2. and the MOE Key Laboratory of Medicinal Chemistry and Molecular Diagnostics

3. Hebei University

4. Baoding 071002

5. People's Republic of China

6. School of Public Health

7. Hebei Medical University

8. Shijiazhuang 050017

9. Center for Analysis and Synthesis

10. Department of Chemistry

11. Lund University

12. SE-221 00 Lund

13. Sweden

Abstract

Studies on oxidation of isoniazid and nicotinic hydrazide by [IrCl₆]²⁻ show that the predominant reactant at physiological pH is a protolytic species present in very low concentration but having extremely high reactivity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/DT/C7DT00885F

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