A study on the trastuzumab conjugation at tyrosine using diazonium salts
Author:
Affiliation:
1. Bayer Pharma AG
2. Global Drug Discovery
3. Medicinal Chemistry Wuppertal
4. 42113 Wuppertal
5. Germany
6. Research Analytics
7. Karlsruher Institut für Technologie (KIT)
8. Institute of Organic Chemistry
9. D-76131 Karlsruhe
Abstract
Herein, we report on the conjugation of trastuzumab with 2,5-difluorobenzene diazonium tetrafluoroborate.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA18271A
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1. Antibody Conjugation Approach Enhances Breadth and Potency of Neutralization of Anti-HIV-1 Antibodies and CD4-IgG
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5. Affinity Labeling by m-Nitrobenzenediazonium Fluoroborate of Porcine Anti-Dinitrophenyl Antibodies. Position of Labeled Tyrosine in the lamba-Chains
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