Combining total synthesis and genetic engineering to probe dihydropyran formation in ambruticin biosynthesis-Reference-Cited by-同舟云学术

Combining total synthesis and genetic engineering to probe dihydropyran formation in ambruticin biosynthesis

Published:2024 Issue:14 Volume:15 Page:5319-5326
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Bowen James I.¹^ORCID,Zhong Xiaotong²^ORCID,Gao Kaining²³^ORCID,Reed Benjamin¹,Crump Matthew P.¹^ORCID,Wang Luoyi²^ORCID,Willis Christine L.¹^ORCID

Affiliation:

1. School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK

2. Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichen West Road, Chaoyang District, Beijing 100101, China

3. School of Life Sciences, Yunnan University, Kunming 650500, China

Abstract

Integrating total synthesis with genetic engineering of Sorangium strains reveal insights into the enzyme-catalysed formation of the 20,21-alkene in ambruticin biosynthesis.

Funder

Engineering and Physical Sciences Research Council

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00720D

Reference39 articles.

1. Ambruticin (W7783), a new antifungal antibiotic.

2. The ambruticins and jerangolids – chemistry, biology and chemoenzymatic synthesis of potent antifungal drug candidates

3. An Overview of Synthetic and Biological Studies of Ambruticin and Analogues

4. In Vivo Studies with Ambruticin in Murine Histoplasmosis

5. On the Mechanism of Action of the Myxobacterial Fungicide Ambruticin.

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