Fluorinated trehalose analogues for cell surface engineering and imaging of <i>Mycobacterium tuberculosis</i>-Reference-Cited by-同舟云学术

Fluorinated trehalose analogues for cell surface engineering and imaging of Mycobacterium tuberculosis

Published:2024 Issue:34 Volume:15 Page:13966-13975
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guy Collette S.¹^ORCID,Gott James A.²^ORCID,Ramírez-Cárdenas Jonathan³,de Wolf Christopher¹,Furze Christopher M.¹,West Geoff²,Muñoz-García Juan C.³^ORCID,Angulo Jesus³^ORCID,Fullam Elizabeth¹^ORCID

Affiliation:

1. School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK

2. WMG, University of Warwick, Coventry, CV4 7AL, UK

3. Instituto de Investigaciones Químicas (IIQ), Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Avenida Américo Vespucio, 49, Sevilla, 41092, Spain

Abstract

The mycobacterial trehalose LpqY-SugABC ATP-binding cassette (ABC) transporter was hijacked to import fluorine-modified trehalose analogues to label cell-surface glycolipids and directly visualise the Mycobacterium tuberculosis pathogen by Focused Ion Beam (FIB) Secondary Ion Mass Spectrometry.

Funder

Leverhulme Trust

Wellcome Trust

Royal Society

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Ministerio de Ciencia e Innovación

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00721B

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