Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase-Reference-Cited by-同舟云学术

Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase

Published:2014 Issue:8 Volume:6 Page:1480-1490
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Luo Zuandi¹²³,Yu Lianling¹²³,Yang Fang¹²³,Zhao Zhennan¹²³,Yu Bo¹²³,Lai Haoqiang¹²³,Wong Ka-Hing⁴⁵⁶,Ngai Sai-Ming⁷⁸⁹,Zheng Wenjie¹²³,Chen Tianfeng¹²³

Affiliation:

1. Department of Chemistry

2. Jinan University

3. Guangzhou 510632, China

4. Department of Applied Biology and Chemical Technology

5. The Hong Kong Polytechnic University

6. Hong Kong, China

7. School of Life Sciences and State Key Laboratory of Agrobiotechnology

8. The Chinese University of Hong Kong

9. Hong Kong SAR, China

Abstract

Ruthenium polypyridyl complexes inhibit cancer growth by targeting TrxR and promote the intracellular ROS generation, ultimately triggering mitochondria-mediated cell apoptosis.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MT/C4MT00044G

Reference84 articles.

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5. The thioredoxin system?From science to clinic

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