Design of abiotic polymer ligand-decorated lipid nanoparticles for effective neutralization of target toxins in the blood-Reference-Cited by-同舟云学术

Design of abiotic polymer ligand-decorated lipid nanoparticles for effective neutralization of target toxins in the blood

Published:2021 Issue:16 Volume:9 Page:5588-5598
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Koide Hiroyuki¹²³⁴⁵^ORCID,Yamauchi Ikumi¹²³⁴⁵,Hoshino Yu⁶⁷⁸⁵^ORCID,Yasuno Go¹²³⁴⁵,Okamoto Takumi¹²³⁴⁵,Akashi Sotaro⁶⁷⁸⁵,Saito Kazuhiro¹²³⁴⁵,Oku Naoto¹²³⁴⁵,Asai Tomohiro¹²³⁴⁵

Affiliation:

1. Department of Medical Biochemistry

2. School of Pharmaceutical Sciences

3. University of Shizuoka

4. Shizuoka

5. Japan

6. Department of Chemical Engineering

7. Kyushu University

8. Fukuoka 819-0395

Abstract

We developed abiotic polymer ligand (PL)-decorated lipid nanoparticles (LNPs) to improve PL mobility, decrease aggregation after capturing the target, and increase the blood circulation time to achieve highly effective toxin neutralization in vivo.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00515D

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